Metabolomics-based biomarkers for lung function

US9823204B2 · kind B2 · utility

Assignee

• Lineagen, Inc. · US

Inventors

• Joseph Louie McClay · Richmond, US
• Barbara K. Zedler · Richmond, US
• Edward Lenn Murrelle · Midlothian, US
• Edwin J. C. G. van den Oord · Richmond, US
• Thomas M. O'Connell · Chapel Hill, US
• Daniel E. Adkins · Richmond, US

Key dates

• Filing date: Jul 3, 2012
• Grant date: Nov 21, 2017
• Expiry date: Jul 3, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/122
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Chronic obstructive pulmonary disease (COPD), characterized by chronic airflow limitation, is a serious and growing public health concern. The major environmental risk factor for COPD is cigarette smoking, but the biological mechanisms underlying COPD are not well understood. Herein, proton nuclear magnetic resonance (1H-NMR) spectroscopy is used in methods to identify metabolites and biomarkers associated with lung function in COPD.