Radio-pharmaceutical complexes

US9827336B2 · kind B2 · utility

Assignee

• Bayer AS · NO

Inventors

• Hanne Therese Bonge-Hansen · Oslo, NO
• Olav Ryan · Maridalen, NO

Key dates

• Filing date: May 13, 2013
• Grant date: Nov 28, 2017
• Expiry date: May 13, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/24
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A tissue-targeting complex comprising a tissue targeting moiety, an octadentate hydroxypyridinone-containing ligand comprising four HOPO moieties and the ion of an alpha-emitting thorium radionuclide, where at least one of the four HOPO moieties is substituted at the N-position with a hydroxyalkyl solubilising group.