Tetrahydro-isohumulone derivatives, methods of making and using

US9828331B2 · kind B2 · utility

Assignee

• KINDEX PHARMACEUTICALS, INC. · US

Inventors

• Veera Konda · Bellevue, US
• Jan Urban · San Diego, US
• Anuradha Desai · Gig Harbor, US
• Clinton J. Dahlberg · Port Orchard, US
• Brian J. Carroll · Gig Harbor, US

Key dates

• Filing date: Jan 9, 2015
• Grant date: Nov 28, 2017
• Expiry date: Jan 9, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides novel tetrahydro-isohumulone (THIAA) derivatives and substantially enantiomerically pure compositions and pharmaceutical formulations thereof. The application further provides methods of using the disclosed compounds and compositions to activate PPARγ, inhibit inflammation, and treat conditions associated with inflammation and conditions responsive to PPARγ modulation such as diabetes.