Isatin derivatives, pharmaceutical compositions thereof, and methods of use thereof

US9828342B2 · kind B2 · utility

Assignees

• City of Hope · US
• The Regents of the University of California · US

Inventors

• David Horne · Duarte, US
• Richard Jove · Duarte, US
• Christopher Lincoln · Corvallis, US
• Sangkil Nam · Duarte, US
• Larry Eugene Overman · Newport Beach, US
• Jun Xie · Singapore, SG

Key dates

• Filing date: Feb 25, 2013
• Grant date: Nov 28, 2017
• Expiry date: Jan 3, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

One aspect of the invention relates to novel isatin derivative compounds and the pharmaceutical composition thereof. Another aspect of the invention relates to methods of using the isatin derivative compounds disclosed herein and the pharmaceutical compositions thereof. In certain embodiments, the method is used to treat a cancer or a tumor in a subject including, without limitation, prostate cancer, melanoma, pancreatic cancer, ovarian cancer, and lymphoma. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the activation of one or more proteins such as EGFR, Erk1/2, Her2/Neu, Jak2, Src, Stat3, Akt, Cyclin B1, and Cdc25C. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the disruption of microtubule formations.