Substituted pyrazolopyrimidines and method of use

US9828381B2 · kind B2 · utility

Assignees

• Abb Vie Deutschland Gmbh & Co. KG · DE
• Abb Vie Inc. · US

Inventors

• Ramin Faghih · Lake Forest, US
• Achim Moeller · Grünstadt, DE
• Michael Ochse · Wiesbaden, DE
• Frauke Pohlki · Wiesbaden, DE
• Martin Schmidt · Frankfurt am Main, DE
• Kevin B. Sippy · Antioch, US
• Sean Turner · Ludwigshafen, DE
• Elizabeth Louise VAN DER KAM · Weesp, NL

Key dates

• Filing date: Apr 20, 2016
• Grant date: Nov 28, 2017
• Expiry date: Apr 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I)and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, L1 and G1 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by positive allosteric modulation of the γ-aminobutyric acid B (GABA-B) receptor. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.