Modified polynucleotides for the production of secreted proteins

US9828416B2 · kind B2 · utility

Assignee

• ModernaTX, Inc. · US

Inventors

• Stephane Bancel · Cambridge, US
• Tirtha Chakraborty · Medford, US
• Antonin de Fougerolles · Waterloo, BE
• Sayda M. Elbashir · Cambridge, US
• Matthias John · Hallstadt, DE
• Atanu Roy · Stoneham, US
• Susan Whoriskey · Belmont, US
• Kristy M. Wood · Wellesley, US
• Paul Hatala · Boston, US
• Jason P. Schrum · Philadelphia, US
• Kenechi Ejebe · New York, US
• Jeff Lynn Ellsworth · Lexington, US
• Justin Guild · Framingham, US

Key dates

• Filing date: Jun 25, 2015
• Grant date: Nov 28, 2017
• Expiry date: Jun 25, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2840/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.