Genes and processes for the production of clavine-type alkaloids

US9828617B2 · kind B2 · utility

Assignees

• BASF SE
• EVOLVA SA · CH

Inventors

• Michael Naesby · Basel, CH
• Christophe Folly · Basel, CH
• Curt Aimé Friis Nielsen · Reinach, CH
• Anaelle Hatsch · Reinach, CH
• Markus Schwab · Bad Kötzting, DE
• Oskar Zelder · Speyer, DE
• Stefan Haefner · Speyer, DE
• Hartwig Schroeder · Greytown, ZA
• Birgit Hoff · Ludwigshafen, DE
• Andrea Molt · Weinheim, DE
• Klaus Ditrich · Neheim, DE
• Michael Breuer · Darmstadt, DE
• Holger Hartmann · Ludwigshafen, DE
• Karsten Koerber · Eppelheim, DE

Key dates

• Filing date: Aug 13, 2013
• Grant date: Nov 28, 2017
• Expiry date: Aug 13, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y205/01
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Microorganisms and processes for the recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde, as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids are provided.