Patent · US Active

Methods and compositions for treating HIV

US9833480B2 · kind B2 · utility

11Cited by
2References
20Claims
0Family size

Assignee

Inventors

Key dates

Filing dateApr 14, 2011
Grant dateDec 5, 2017
Priority date—
Expiry dateJun 25, 2034

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2799/027
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

The invention features nucleic acid constructs encoding chimeric immune T-cell receptors (CIRs) that are useful for treating HIV in patients. In general, the CIRs contain an extracellular domain which targets HIV or HIV infected cells (e.g., the extracellular domain of CD4), a transmembrane domain, and a cytoplasmic domain for mediating T-cell activation (e.g., CD3 zeta and/or the partial extracellular domain of CD28). The invention also features the use of host cells expressing CIRs in the treatment of HIV.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.