Methods of treatment of collagen-mediated diseases and conditions
US9833498B2 · kind B2 · utility
3Cited by
108References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 6, 2009 |
| Grant date | Dec 5, 2017 |
| Priority date | — |
| Expiry date | Mar 6, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/24007
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and combinations are provided for controlling the duration of action, in vivo, of matrix-degrading enzymes. The methods and combinations permit temporary in-vivo activation of matrix-degrading enzymes upon administration to the extra cellular matrix (or “ECM”). Matrix-degrading enzymes having a controlled duration of action can be used to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.