Patent · US Active

Macrocyclic urea derivatives as inhibitors of TAFIa, their preparation and their use as pharmaceuticals

US9834527B2 · kind B2 · utility

0Cited by

4References

9Claims

0Family size

Assignee

Sanofi · FR

Inventors

Andreas Evers · Frankfurt am Main, DE
Christopher Kallus · Frankfurt am Main, DE
Michael Wagner · Frankfurt am Main, DE
Hermut Wehlan · Frankfurt am Main, DE

Key dates

Filing date	Jun 5, 2014
Grant date	Dec 5, 2017
Priority date	—
Expiry date	Jun 5, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D413/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.