Patent · US Active

Pyridin-2(1H)-one quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors

US9834539B2 · kind B2 · utility

24Cited by

2References

108Claims

0Family size

Assignee

FORMA Therapeutics, Inc. · US

Inventors

Jian Lin · Watertown, US
Anna Ericsson · Keyano, CA
Ann-Marie Campbell · Monroe, US
Gary Gustafson · Ridgefield, US
Zhongguo Wang · Lexington, US
R. Bruce Diebold · Waltham, US
Susan Ashwell · Plainsboro, US
David R. Lancia, Jr. · Boston, US
Justin Andrew Caravella · Cambridge, US
Wei Lu · Newton, US

Key dates

Filing date	Sep 18, 2015
Grant date	Dec 5, 2017
Priority date	—
Expiry date	Sep 18, 2035

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K31/47
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula:where A, U, W1, W2, W3, R1-R6, and R9 are described herein.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.