Populations of hematopoietic progenitors and methods of enriching stem cells therefor
US9834754B2 · kind B2 · utility
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Key dates
| Filing date | Nov 21, 2012 |
| Grant date | Dec 5, 2017 |
| Priority date | — |
| Expiry date | Nov 21, 2032 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/70596
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of CD43 and at least one of CD34, CD31 and CD144; and selecting a fraction that is at least one of CD34+CD43−, CD31+CD43− and CD144+CD43−. Also provided are populations of hematopoietic progenitors obtained by the methods described herein.
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