Recombinant cells and organisms having persistent nonstandard amino acid dependence and methods of making them
US9834775B2 · kind B2 · utility
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Key dates
| Filing date | Sep 26, 2014 |
| Grant date | Dec 5, 2017 |
| Priority date | — |
| Expiry date | Sep 26, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/102
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.
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