Ventricular activation (RR) entropy change as a predictor of sudden cardiac death in cardiac resynchronization therapy patients

US9839364B2 · kind B2 · utility

Assignees

• University of Virginia Patent Foundation · US
• THE JOHNS HOPKINS UNIVERSITY · US

Inventors

• J. Randall Moorman · Charlottesville, US
• Douglas E. Lake · Charlottesville, US
• Gordon Tomaselli · Timonium, US
• Deeptankar DeMazumder · Baltimore, US

Key dates

• Filing date: May 11, 2013
• Grant date: Dec 12, 2017
• Expiry date: May 11, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/352
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.