Compositions and methods for preventing sternal wound infections
US9839628B2 · kind B2 · utility
0Cited by
36References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 1, 2010 |
| Grant date | Dec 12, 2017 |
| Priority date | — |
| Expiry date | Jun 1, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.