Compartmentalised combinatorial chemistry by microfluidic control
US9839890B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 12, 2005 |
| Grant date | Dec 12, 2017 |
| Priority date | — |
| Expiry date | Aug 11, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2035/1034
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control, The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.