Lysine isotopologues, compositions comprising the same and methods of synthesis

US9840457B2 · kind B2 · utility

Assignee

• Cambridge Isotope Laboratories, Inc. · US

Inventors

• Joel Chandler Bradley · Cambridge, US
• William W. Wood · Pennington, US
• Salim Barkallah · Tewksbury, US
• William James Ryan · Westford, US
• Richard C. Titmas · Rockville, US
• Mark D. Schwinden · Holland, US
• Janusz Konrad Kozak · Methuen, US
• Marwan ElMasri · Groton, US
• Steven M. Torkelson · Lawrence, US

Key dates

• Filing date: Mar 12, 2014
• Grant date: Dec 12, 2017
• Expiry date: Mar 12, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/05
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention relates to lysine isotopologues of Formulas I and 1-A, as described herein, and processes for synthesizing the same and derivatives and intermediates involved therein. In one aspect, described herein is a chemical compound comprising an isotopically labeled analog, i.e., an isotopologue of a standard or naturally occurring lysine. The lysine isotopologue is synthetically formed to have stable isotopes of elements incorporated at selected positions. As such, the lysine isotopologue has a molecular mass different from the mass of a standard or naturally occurring lysine.