Patent · US Active

Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use

US9840493B2 · kind B2 · utility

17Cited by

2References

9Claims

0Family size

Assignee

Sutro Biopharma, Inc. · US

Inventors

Wenjin Yang · Foster City, US
Qun Yin · Palo Alto, US

Key dates

Filing date	Oct 10, 2014
Grant date	Dec 12, 2017
Priority date	—
Expiry date	Oct 10, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y601/01001
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are modified amino acids comprising a tetrazine groups according to Formula I: polypeptides, antibodies, payloads and conjugates comprising these modified amino acid residues derived from the modified amino acids, and methods of producing the polypeptides, antibodies, payloads and conjugates comprising the modified amino acid residues. The polypeptides, antibodies, payloads and conjugates are useful in methods of treatment and prevention, methods of detection and methods of diagnosis.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.