Compositions comprising nanostructures for cell, tissue and artificial organ growth, and methods for making and using same

US9844657B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Sungho Jin · Millington, US
• Seunghan Oh · Gaegun-myeon, KR

Key dates

• Filing date: Feb 12, 2016
• Grant date: Dec 19, 2017
• Expiry date: Feb 12, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2037/0007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides articles of manufacture comprising biocompatible nanostructures comprising nanotubes and nanopores for, e.g., organ, tissue and/or cell growth, e.g., for bone, kidney or liver growth, and uses thereof, e.g., for in vitro testing, in vivo implants, including their use in making and using artificial organs, and related therapeutics. The invention provides lock-in nanostructures comprising a plurality of nanopores or nanotubes, wherein the nanopore or nanotube entrance has a smaller diameter or size than the rest (the interior) of the nanopore or nanotube. The invention also provides dual structured biomaterial comprising micro- or macro-pores and nanopores. The invention provides biomaterials having a surface comprising a plurality of enlarged diameter nanopores and/or nanotubes.