Treprostinil derivative compounds and methods of using same

US9845305B2 · kind B2 · utility

Assignee

• Corsair Pharma, Inc. · US

Inventors

• Cyrus K. BECKER · Fremont, US
• Jurg R. Pfister · Los Altos, US
• Gwenaella Rescourio · Thousand Oaks, US
• Meenakshi S. Venkatraman · Fremont, US
• Xiaoming Zhang · Beijing, CN

Key dates

• Filing date: Oct 18, 2016
• Grant date: Dec 19, 2017
• Expiry date: Oct 18, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.