Intermediates for preparing triazole agonists of the APJ receptor

US9845310B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Ning Chen · Thousand Oaks, US
• Xiaoqi Chen · Palo Alto, US
• Alan C. Cheng · Cambridge, US
• Richard V. Connors · Mesa, US
• Jeffrey Deignan · San Francisco, US
• Paul John Dransfield · Arlington, US
• Xiaohui Du · Foster City, US
• Zice Fu · Foster City, US
• Julie Anne Heath · Chico, US
• Daniel B. Horne · Natick, US
• Jonathan Houze · Cambridge, US
• Matthew R. Kaller · Ventura, US
• David John Kopecky · West Hollywood, US
• Su-Jen Lai · Somerville, US
• Zhihua Ma · Lexington, US
• Lawrence R. McGee · Pacifica, US
• Julio C. Medina · Redwood City, US
• Jeffrey T. Mihalic · San Francisco, US
• Nobuko Nishimura · Calabasas, US
• Steven H. Olson · Millbrae, US
• Vatee Pattaropong · Bedford, US
• Xiaodong Wang · Zhejiang, CN
• Kevin Yang · San Gabriel, US
• Mikkel V. Debenedetto · Shrewsbury, US
• Simon J. Hedley · Thousand Oaks, US

Key dates

• Filing date: Oct 20, 2016
• Grant date: Dec 19, 2017
• Expiry date: Oct 20, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula VII, salts thereof, tautomers thereof, and salts of the tautomers are useful intermediates in the synthesis of agonists of the APJ Receptor. Compounds of Formula VII have the following structure:where the definitions of the variables are provided herein.