System and method for patient specific modeling of liver tumor ablation

US9846765B2 · kind B2 · utility

Assignees

• Siemens Healthcare Limited · DE
• INRIA · FR

Inventors

• Chloe Audigier · Valbonne, FR
• Tommaso Mansi · Plainsboro, US
• Viorel Mihalef · New Brunswick, US
• Ali Kamen · Skillman, US
• Dorin Comaniciu · Princeton Junction, US
• Puneet Sharma · Rahway, US
• Saikiran Rapaka · Ewing, US
• Herve Delingette · Antibes, FR
• Nicholas Ayache · Nice, FR

Key dates

• Filing date: Nov 5, 2013
• Grant date: Dec 19, 2017
• Expiry date: Jan 14, 2036

Classification

• Technology area (CPC G): Physics
• CPC primary: G16H20/40
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method and system for tumor ablation planning and guidance based on a patient-specific model of liver tumor ablation is disclosed. A patient-specific anatomical model of the liver and circulatory system of the liver is estimated from 3D medical image data of a patient. Blood flow in the liver and the circulatory system of the liver is simulated based on the patient-specific anatomical model. Heat diffusion due to ablation is simulated based on a virtual ablation probe position and the simulated blood flow in the liver and the venous system of the liver. Cellular necrosis in the liver is simulated based on the simulated heat diffusion. A visualization of a simulated necrosis region is generated and displayed to the user for decision making and optimal therapy planning and guidance.