Methods and compositions for X-ray induced release from pH sensitive liposomes

US9849087B2 · kind B2 · utility

Assignee

• THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS · US

Inventors

• Daniel Fologea · Boise, US
• Ralph Henry · Fayetteville, US
• Greg Salamo · Fayetteville, US
• Yuriy Mazur · Fayetteville, US
• Michael J. Borrelli · Little Rock, US

Key dates

• Filing date: Nov 8, 2012
• Grant date: Dec 26, 2017
• Expiry date: Jan 17, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions including pH sensitive lipid vesicles comprised of a lipid layer, an agent, and an organic halogen such that the agent is released from the vesicles after exposure to ionizing radiation. Methods of delivering the agent to a target in a subject using the compositions provided herein are also described. The methods allow for controlled release of the agent. The timing of release of the agent from the lipid vesicle may be controlled as well as the location of release by timing and localizing the exposure to ionizing radiation exposure.