Inhibition of nonsense mediated mRNA decay by drugs that prevent hypusination of eukaryotic initiation factor 5A
US9849146B2 · kind B2 · utility
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Key dates
| Filing date | Jun 13, 2012 |
| Grant date | Dec 26, 2017 |
| Priority date | — |
| Expiry date | Aug 10, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K45/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are methods for treating a NAD comprising administering to a patient suffering from a NAD an inhibitor of NMD and a nonsense suppressor, whereby degradation of NMD susceptible mRNA is decreased and translation termination at a misplaced nonsense codon is blocked.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.