Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds

US9850198B2 · kind B2 · utility

Assignee

• Gruenenthal GmbH · DE

Inventors

• Helmut Buschmann · Walheim, DE
• Joerg Holenz · Barcelona, ES

Key dates

• Filing date: May 17, 2016
• Grant date: Dec 26, 2017
• Expiry date: May 17, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.