Patent · US Active

Beta-hairpin peptidomimetics

US9850284B2 · kind B2 · utility

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12Claims

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Assignee

POLYPHOR AG · CH

Inventors

Daniel Obrecht · Amriswil, CH
Anatol Luther · Binzen, DE
Francesca Bernardini · Hésingue, FR
Peter ZBINDEN · Magden, CH

Key dates

Filing date	Mar 28, 2014
Grant date	Dec 26, 2017
Priority date	—
Expiry date	Mar 28, 2034

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02A50/30
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Beta-hairpin peptidomimetics of the general formula (I), cyclo(P1-p2-p3-p4-p5-p6-p7p8p9-p10-p11-p12-T1-T2], and pharmaceutically acceptable salts thereof, with P1 to P12, T1 and T2 being elements as defined in the description and the claims, have broad spectrum Gram-negative antimicrobial activity to e.g. inhibit the growth or to kill microorganisms such as Klebsiella pneumoniae and/or Acinetobacter baumannii and/or Escherichia coli. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.