Patent · US Active

Methods of stapling and unstapling peptides and proteins

US9850469B2 · kind B2 · utility

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15Claims

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Assignee

The Trustees of the University of Pennsylvania · US

Inventors

Amos B. Smith, III · Yeadon, US
Stephen Brown · Philadelphia, US

Key dates

Filing date	Mar 17, 2015
Grant date	Dec 26, 2017
Priority date	—
Expiry date	Mar 17, 2035

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K7/54
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure pertains to the field peptide stapling and/or macrocyclization, where a structural motif is used to improve the properties of amino acid sequences (e.g. protease resistance, cellular penetration, biological activity). Also within the scope of the disclosure are methods for unstapling the S,S-tetrazine-containing amino acid sequence. The disclosure is also directed to methods for the reductive removal of thiocyanates from an amino acid sequence with cysteine to recycle back to the native amino acid sequence.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.