Biosensor system for the rapid detection of analytes
US9850546B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 6, 2017 |
| Grant date | Dec 26, 2017 |
| Priority date | — |
| Expiry date | Jul 6, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/245
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is ada…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.