Patent · US Active

Tamper-resistant dosage form with immediate release and resistance against solvent extraction

US9855263B2 · kind B2 · utility

13Cited by

209References

21Claims

0Family size

Assignee

GRÜNENTHAL GMBH · DE

Inventors

KLAUS WENING
ANJA GEIßLER · Stolberg, DE
JANA DENKER · Bornheim, DE
Lutz Barnscheid · Mönchengladbach, DE

Key dates

Filing date	Jun 1, 2016
Grant date	Jan 2, 2018
Priority date	—
Expiry date	Jun 1, 2036

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/36
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A tamper-resistant pharmaceutical dosage form comprising a multitude of particles which comprise a pharmacologically active compound, a polyalkylene oxide, and a disintegrant; wherein the pharmacologically active compound is dispersed in a matrix comprising the polyalkylene oxide and the disintegrant; wherein the content of the disintegrant is more than 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; wherein the content of the polyalkylene oxide is at least 25 wt.-%, based on the total weight of the pharmaceutical dosage form and/or based on the total weight of the particles; and wherein the dosage form provides under in vitro conditions immediate release of the pharmacologically active compound in accordance with Ph. Eur.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.