Hydrogel prodrugs

US9855340B2 · kind B2 · utility

Assignee

• ASCENDIS PHARMA A/S · DK

Inventors

• Harald Rau · Würzburg, DE
• Tobias Voigt · Heidelberg, DE
• Burkhardt Laufer · Birkenfeld, DE
• Nicola Bisek · Heidelberg, DE
• Franziska Hahn · Stuttgart, DE
• Thomas Knappe · Heidelberg, DE

Key dates

• Filing date: Oct 8, 2013
• Grant date: Jan 2, 2018
• Expiry date: Oct 8, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08L2203/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a process for the preparation of a hydrogel and to a hydrogel obtainable by said process. The present invention further relates to a process for the preparation of a hydrogel-spacer conjugate, to a hydrogel-spacer conjugate obtainable by said process, to a process for the preparation of a carrier-linked prodrug and to carrier-linked prodrugs obtainable by said process, in particular to carrier-linked prodrugs that provide for a controlled or sustained release of a drug from a carrier. In addition, the invention relates to the use of the hydrogel for the preparation of a carrier-linked prodrug.