Radio-labelled antibody fragments for use in the prevention and/or treatment of cancer
US9855348B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 17, 2015 |
| Grant date | Jan 2, 2018 |
| Priority date | — |
| Expiry date | Oct 14, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The application provides polypeptides comprising or essentially consisting of at least one heavy chain variable domain of a heavy chain antibody (VHH) or functional fragments thereof, wherein said VHH or functional fragment thereof specifically binds to a target protein that is present on and/or specific for a solid tumor or cancer cell, e.g., HER2. The application further provides nucleic acids encoding such polypeptides; methods for preparing such polypeptides; host cells expressing or capable of expressing such polypeptides; compositions, and in particular to pharmaceutical compositions that comprise such polypeptides, nucleic acids and/or host cells. The application further provides such polypeptides, nucleic acids, host cells and/or compositions, for use in methods for the prevention and/or treatment of cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.