Peptides capable of reactivating p53 mutants
US9856289B2 · kind B2 · utility
3Cited by
1References
32Claims
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Assignee
Inventors
Key dates
| Filing date | Feb 4, 2016 |
| Grant date | Jan 2, 2018 |
| Priority date | — |
| Expiry date | Feb 4, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and isolation of such peptides, in a precise, cost and time effective manner. In particular, there are provided mutant p53 reactivating peptides that can restore the native wild type p53 folding, and hence the tumor suppressor activity, to the mutant p53 protein. Such peptides are useful for treating various conditions and diseases in which p53 is mutated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.