Antibodies targeting M-CSF

US9856316B2 · kind B2 · utility

Assignee

• MORPHOSYS AG · DE

Inventors

• Francis Dodeller · Gilching, DE
• Robert Rauchenberger · Martinsried, DE

Key dates

• Filing date: Apr 11, 2014
• Grant date: Jan 2, 2018
• Expiry date: Apr 13, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This disclosure generally relates to antibodies or antibody fragments which specifically bind to M-CSF. In particular antibodies and antibody fragments are disclosed which bind to M-CSF and which inhibit binding of M-CSF to the M-CSF receptor with an IC50 of 10 pM or less. The invention also relates to nucleic acids, vectors and host cells capable of expressing the antibodies or fragments thereof of the invention, pharmaceutical compositions comprising the antibodies or fragments thereof and uses of said antibodies or fragments thereof and compositions for treatment of specific diseases.