Methods and arrays for controlled manipulation of DNA and chromatin fragments for genetic and epigenetic analysis
US9856513B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 28, 2013 |
| Grant date | Jan 2, 2018 |
| Priority date | — |
| Expiry date | Jan 6, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N1/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to methods and arrays for use in high resolution imaging of individual nucleic acid molecules and chromatin fragments, including native chromatin fragments. In one aspect, the present invention relates to a chromatin array that includes a transfer platform having a support and a transfer surface layered on the support. The chromatin array also includes a plurality of elongated individual native chromatin fragments coupled to the transfer surface in an orderly pattern suitable for high resolution imaging of the plurality of native chromatin fragments. The native chromatin fragments of the chromatin array include both DNA and histones.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.