Profiling fragments of elastic fibers and microfibrils as biomarkers for disease
US9857380B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Oct 25, 2011 |
| Grant date | Jan 2, 2018 |
| Priority date | — |
| Expiry date | Mar 18, 2034 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/329
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention makes use of immunoassays, such as sandwich ELISAs, to profile the circulating concentration of elastic fiber and microfibril fragments in samples from individuals with diseases associated with elastic fiber and/or microfibril degradation. Examples of such diseases include, Marfan's syndrome, aortic aneurysm, and scleroderma. Profiling the concentration of such fragments can be used to diagnose disease and monitor disease progression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.