Conjugates of an IL-2 moiety and a polymer

US9861705B2 · kind B2 · utility

Assignee

• Nektar Therapeutics · US

Inventors

• Mary J. Bossard · Madison, US
• Cherie F. Ali · Burlingame, US
• Xiaofeng Liu · Dallas, US
• Deborah H. Charych · Albany, US
• Yujun Wang · Columbus, US

Key dates

• Filing date: Nov 11, 2011
• Grant date: Jan 9, 2018
• Expiry date: Nov 11, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.