Patent · US Active

Difluoroboron dipyrromethene fluorescent probe, production method and application thereof

US9862731B2 · kind B2 · utility

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13Claims

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Assignee

Dalian University of Technology · CN

Inventors

Jiangli Fan · 东风镇, CN
Hao Zhu · Freising, DE
Xiaojun Peng · Dalian, CN
Jingyun Wang · 东风镇, CN

Key dates

Filing date	Nov 26, 2014
Grant date	Jan 9, 2018
Priority date	—
Expiry date	Nov 26, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC09K2211/1029
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2−, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.