Patent · US Active

Growth differentiation factor 15 (GDF-15) constructs

US9862752B2 · kind B2 · utility

15Cited by

5References

27Claims

0Family size

Assignee

AMGEN INC. · US

Inventors

Yumei Xiong · Palo Alto, US
Yi Zhang · Nanjing, CN
Jackie Z. Sheng · Thousand Oaks, US
Agnes Eva Hamburger · Newbury Park, US
Murielle Veniant-Ellison · Thousand Oaks, US
Grant Shimamoto · Newbury Park, US
Xiaoshan MIN · Burlingame, US
Zhulun Wang · Palo Alto, US
Jie Tang · Singapore, SG
Gunasekaran Kannan · Daly City, US
Marissa MOCK · Newbury Park, US
Kenneth W. Walker · Newbury Park, US

Key dates

Filing date	Jul 31, 2014
Grant date	Jan 9, 2018
Priority date	—
Expiry date	Jul 31, 2034

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/31
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.