Inhibitor targeting specific complement system, and preparation method and use thereof
US9862757B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 3, 2014 |
| Grant date | Jan 9, 2018 |
| Priority date | — |
| Expiry date | Jul 9, 2034 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An inhibitor targeting specific complement, the inhibitor targeting specific complement is a protein, the protein has a targeted inhibition function on the complement activation, and the amino acid sequence of the protein comprises CRIg extracellular domain and complement inhibiting domain; the amino acid sequence of the protein is consist of the CRIg extracellular domain and the complement inhibiting domain connected directly, or indirectly through a linker which can connect the two domains. The preparation method of the inhibitor targeting specific complement comprises connecting the protein polypeptides of the CRIg extracellular domain and the complement inhibiting domain by gene engineering technology. The protein can be used to prepare a drug targeting inhibition of complement activation. The inhibitor targeting specific complement, its preparation method and applications provided by the present invention, can be used in the treatment and prevention of human diseases caused by complement activation disorders. It has great potential application value and development prospects.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.