Patent · US Active

Method for the inhibition of angiogenesis

US9862949B2 · kind B2 · utility

2Cited by

0References

2Claims

0Family size

Assignee

T2CURE GMBH · DE

Inventors

Stefanie Dimmeler · Frankfurt am Main, DE
Andreas M. Zeiher · Glückstadt, DE
Angelika Bonauer · Frankfurt, DE
Carmen Urbich · Goldkronach, DE

Key dates

Filing date	Feb 10, 2016
Grant date	Jan 9, 2018
Priority date	—
Expiry date	Feb 10, 2036

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2320/50
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.