Use of aptamers in therapy and/or diagnosis of autoimmune diseases

US9862953B2 · kind B2 · utility

Assignees

• CHARITÉ—UNIVERSITÄTSMEDIZIN BERLIN · DE
• MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER · DE

Inventors

• Ingolf Schimke · Berlin, DE
• Annekathrin Haberland · Berlin, DE
• Gerd Wallukat · Berlin, DE

Key dates

• Filing date: Dec 22, 2015
• Grant date: Jan 9, 2018
• Expiry date: Dec 22, 2035

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is directed to an aptamer comprising or consisting of the nucleic acid sequence of SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 and/or a nucleic acid sequence being at least 80% identical to one of SEQ ID No. 1, 2 and 3 for use in therapy and/or diagnosis of autoimmune diseases, wherein the autoimmune disease is cardiomyopathy, dilated cardiomyopathy (DCM), peripartum cardiomyopathy (PPCM), idiopathic cardiomyopathy, Chagas' cardiomyopathy, Chagas' megacolon, Chagas' megaesophagus, Chagas' neuropathy, benign prostatic hyperplasia, scleroderma, psoriasis, Raynaud syndrome, pre-eclamsia, kidney allograft rejection, myocarditis, glaucoma, hypertension, pulmonary hypertension, malignant hypertension, and/or Alzheimer's disease.