Hypromellose-graft-chitosan and methods thereof for sustained drug delivery
US9867787B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Apr 15, 2016 |
| Grant date | Jan 16, 2018 |
| Priority date | — |
| Expiry date | Apr 15, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2400/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein is a drug delivery system, which is based on a novel polymer namely hypromellose-graft-chitosan (HC), useful to deliver a drug to a patient in sustained and controlled release fashion. HC is highly water soluble across the pH range from 1.2 to 10, and has a high pH buffering capacity to provide a pH-stable environment for drug delivery. In addition, the drug delivery system provided herein exhibited a drug loading efficiency of over 90% in all drugs tested, which is 1-2 fold higher than the efficiency attainable by conventional chitosan, and achieved a 2-3 fold longer duration of sustained drug release.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.