Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO)

US9867879B2 · kind B2 · utility

Assignee

• VANDERBILT UNIVERSITY · US

Inventors

• Eric P. Skaar · Brentwood, US
• Matthew Surdel · Nashville, US
• Gary A. Sulikowski · Brentwood, US
• Brendan F. Dutter · Nashville, US
• Paul R. Reid · Durham, US
• Alex G. Waterson · Durham, US

Key dates

• Filing date: Jan 22, 2016
• Grant date: Jan 16, 2018
• Expiry date: Jan 22, 2036

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y103/03004
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for treating a microbial infection involves administering an effective amount of a compound of the formula:wherein R1 is H, alkyl, aryl, heteroaryl, R2 is H, halogen, alkyl, aryl, heteroaryl, R3 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R4 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R5 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R6 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R7 is H, hydroxyl, alkoxy, alkyl, aryl, heteroaryl, amino, amino sulfonyl, acetamide, R8 is —CR3, O, S, wherein R5 and R6, R7 and R6, R5 and R4, R4 and R3 can cyclize forming a 3-10 member ring comprising C, O, S, and/or N optionally substituted with one or more R3; and administering light therapy, such as a photodynamic therapy (PDT) light source.