Block copolymers

US9867885B2 · kind B2 · utility

Assignee

• PhaseRx, Inc. · US

Inventors

• Sean D. Monahan · Madison, US
• Michael S. DeClue · Seattle, US
• Pierrot Harvie · Bothell, US
• Russell N. JOHNSON · Seattle, US
• Amber E.E. Paschal · Redmond, US
• Mary G. Prieve · Lake Forest Park, US
• Debashish Roy · Seattle, US
• Charbel Diab · Tustin, US
• Michael E. Houston, JR. · Sammamish, US
• Anna Galperin · Seattle, US
• Maher QABAR · Sammamish, US

Key dates

• Filing date: Jul 30, 2014
• Grant date: Jan 16, 2018
• Expiry date: Jul 30, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y113/12007
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described herein are block copolymers, and methods of making and utilizing such copolymers. The described block copolymers are disruptive of a cellular membrane, including an extracellular membrane, an intracellular membrane, a vesicle, an organelle, an endosome, a liposome, or a red blood cell. Preferably, in certain instances, the block copolymer disrupts the membrane and enters the intracellular environment. In specific examples, the block copolymer is endosomolytic and capable of delivering an oligonucleotide (e.g., an mRNA) to a cell. Compositions comprising a block copolymer and an oligonucleotide (e.g., an mRNA) are also disclosed.