Rapamycin 40-O-cyclic hydrocarbon esters, compositions and methods
US9867911B2 · kind B2 · utility
1Cited by
1References
4Claims
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Key dates
| Filing date | Jul 18, 2016 |
| Grant date | Jan 16, 2018 |
| Priority date | — |
| Expiry date | Jul 18, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/608
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A new class of rapamycin 40-O-cyclic hydrocarbon esters is disclosed. The 40-O position of the rapamycin ester has the form 40-O—R, where R is C(O)—(CH2)n-X, n is 0, 1 or 2, and X is a cyclic hydrocarbon having 3-8 carbons, optionally containing one or more unsaturated bonds, and one or more linear (CH2)) and/or cyclic (X) carbon atoms may have an OH or halide group. Also disclosed are therapeutic compositions and methods that employ the novel analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.