Tetra-aryl cyclobutane inhibitors of androgen receptor action for the treatment of hormone refractory cancer

US9868705B2 · kind B2 · utility

Assignees

• The Board of Trustees of the University of Illinois · US
• Duke University · US

Inventors

• John A. Katzenellenbogen · Urbana, US
• Donald P. McDonnell · San Diego, US
• John Norris · Raleigh, US
• Alexander Parent · Medford, US
• Julie Pollock · Durham, US
• Jillian Gunther · Houston, US
• Kathryn E. Carlson · Champaign, US
• Teresa Alejandra Trejo Martin · Oak Ridge, US

Key dates

• Filing date: Sep 25, 2014
• Grant date: Jan 16, 2018
• Expiry date: Sep 25, 2034

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F23K2203/103
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.