Apigenin analogs, compositions, and methods related thereto
US9868715B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Apr 18, 2015 |
| Grant date | Jan 16, 2018 |
| Priority date | — |
| Expiry date | Apr 18, 2035 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D407/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (CBS) inhibitors. In certain aspects, the derivatives are used as anticancer or anti-inflammatory agents. Certain embodiments are directed methods of treating or compositions used to treat fibrosis and cancers. In certain aspects one or more compounds described herein can be administered to a subject to treat pancreatic fibrosis, liver fibrosis, pancreatic cancer, colon cancer, breast cancer, brain tumors, head/neck cancer, prostate and lung cancers as well as other inflammation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.