Conjugate of benzofuranone and indole or azaindole, and preparation and uses thereof

US9868734B2 · kind B2 · utility

Assignee

• Luoda Biosciences, Inc. · CN

Inventors

• Qizheng Yao · 安丰镇, CN
• Jiajia Liu · Beijing, CN
• Zhaohui Wang · Chapel Hill, US
• Kui Wu · Tucson, US
• Yongbin Wang · Lo Wu, CN
• Shining Yao · 安丰镇, CN
• Ruihuan Chen · Meekrap-oord, CN
• Beibei Yang · Meekrap-oord, CN

Key dates

• Filing date: May 26, 2014
• Grant date: Jan 16, 2018
• Expiry date: May 26, 2034

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an oxo indirubin or isoindigo derivative, an oxo aza indirubin or isoindigo derivative, and their optical isomers, racemes, cis/trans isomers and pharmaceutically acceptable salts, which can be used for preparing a drug for treating or preventing diseases such as glucose metabolic disorder, inflammatory or autoimmune disease, neurodegenerative disease, a mental illness, tissue proliferation disease or tumors.