Marinopyrrole derivatives and methods of making and using same

US9868747B2 · kind B2 · utility

Assignees

• H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE INC. · US
• CHONGQING ZEIN PHARMACEUTICAL CO., LTD · CN

Inventors

• Rongshi Li · Omaha, US
• Said M. Sebti · Tampa, US
• Yan Liu · Tangshan City, CN
• Yong Qin · Chongqing, CN
• Hao Song · Sunnyvale, US
• Chunwei Cheng · Leeds, GB

Key dates

• Filing date: Feb 18, 2015
• Grant date: Jan 16, 2018
• Expiry date: Feb 18, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6561
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.