Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US9868948B2 · kind B2 · utility
24Cited by
51References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 8, 2013 |
| Grant date | Jan 16, 2018 |
| Priority date | — |
| Expiry date | May 10, 2033 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.